Main Host Institution: Hospital Germans Trias i Pujol Health Sciences Institute (HGTP), Badalona – Spain
Host Lab: Cancer Biology and Precision Medicine
Project Title: miRNA profiling in CD47-enriched exosomes
Project Background: CD47 is a well-known “don’t eat me” protein that when expressed on cancer cells, leads to immune-evasion and inhibition of phagocytosis by macrophages. CD47 was recently also found present on the surface of exosomes. The composition of exosome-surface markers is known to mimic that of the cell of origin, and therefore to carry a cell-specific cargo with functional properties, like microRNAs (miRNAs).