Main Host Institution: Hospital Germans Trias i Pujol Health Sciences Institute (HGTP), Badalona – Spain

Host Lab: Cancer Biology and Precision Medicine

Project Title: miRNA profiling in CD47-enriched exosomes

Project Background: CD47 is a well-known “don’t eat me” protein that when expressed on cancer cells, leads to immune-evasion and inhibition of phagocytosis by macrophages. CD47 was recently also found present on the surface of exosomes. The composition of exosome-surface markers is known to mimic that of the cell of origin, and therefore to carry a cell-specific cargo with functional properties, like microRNAs (miRNAs).

Project Aim:

• The aim of the project is miRNA profiling in CD47-enriched exosomes for establishment of a miRNA panel to predict response for immunotherapy at the baseline.
• Assess early response after treatment.
• Mainly to control the risk of severe adverse effects before they appear.