Main Host Institution: Amsterdam University Medical Centre (Amsterdam UMC)
Host Lab: Neuro-Oncology Group
Project Title: Diagnostic utility of nucleic acid composition in TEPs from NSCLC patients
Project Background: The blood samples from cancer patients contain platelets can be a source of cancer biomarkers. The focus of my PhD Project is to improve and standardize methods using Tumor Educated Platelets (TEPs) for early stage Non-Small-Cell Lung Cancer (NSCLC) detection and characterization.
Project Aim:
NSCLC blood samples collection and processing, including biobanking and database procedures for optimal sample utilization.
Automation of the ThromboSeq protocol and validation of the algorithm in the detection and stratification of early stage NSCLC patients.
Development and evaluation of clinical utility of TEPs assays integrated with other biosources, for companion diagnostics and therapy stratification.
Computational multimodal approach to integrate multiple clinical and biomarkers data into clinical advice.